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The addition of bortezomib to the standard induction therapy before double autologous stem-cell transplantation for patients with multiple myeloma appears to improve nearly threefold the rates of complete or near-complete response, according to research published online in The Lancet, HealthDay News reported.

Further reductions in LDL cholesterol through more intensive statin regimens safely produce definite further reductions in vascular events, even down to very low LDL levels, lower than current targets, according to the results of 2 meta-analyses, The Lancet reported. There was no evidence of any lower threshold where the benefit is not seen.

A key provision of the Affordable Care Act kicked in January 1 when Medicare beneficiaries who have Part D but don?t get the low-income subsidy ?Extra Help? began receiving a 50% discount under the Medicare Coverage Gap Discount Program on applicable drugs at point of sale. The following article explains how pharmacies should prepare.

Many serious or potentially fatal adverse reactions associated with new, targeted anti-cancer agents are not reported in the original published research on the drug, and they are not known to oncologists until years later when drug labels are updated, including boxed warnings, according to research published online in the Journal of Clinical Oncology, HealthDay News reported.

Patients who are newly treated with statin-fibrate concurrent therapy are slightly more likely to be hospitalized with rhabdomyolysis than those who take just one of the medications, according to research published in the American Journal of Cardiology, HealthDay News reported.

Many serious or potentially fatal adverse reactions associated with new, targeted anti-cancer agents are not reported in the original published research on the drug, and they are not known to oncologists until years later when drug labels are updated, including boxed warnings, according to research published online in the Journal of Clinical Oncology, HealthDay News reported.

State Medicaid programs could save $30 billion over the next decade by replacing fee for service pharmacy programs with managed care programs like those used in Medicare Part D, according to a new report on Medicaid pharmacy spending sponsored by the Pharmaceutical Care Management Association.

Patients who switch statins have lower persistence to therapy compared to those who don?t switch, according to a poster recently presented at the 45th midyear meeting of the American Society of Health-Systems Pharmacists.

In a multi-national, placebo-controlled, double-blind trial, the selective vitamin D receptor activator paricalcitol (Zemplar, Abbott Laboratories), at doses of 1 µg or 2 µg daily, can reduce albuminuria in patients with type 2 diabetes, who were already being treated with renin-angiotensin-aldosterone system inhibitors.

In research published in the October 1 issue of the American Journal of Cardiology, HealthDay News reported, metformin, either alone or in combination with sulfonylurea, appears to increase 1-year and long-term survival in patients with T2DM and CHF.