The occasional occurrence of severe congestive heart failure and left ventricular dysfunction with use of imatinib (Gleevec) has prompted manufacturer Novartis to revise the Precautions section of the prescribing information. According to the company, most patients experiencing cardiac events had other comorbidities and risk factors, including a prior medical history of cardiac disease and advanced age. At-risk patients should be monitored carefully, and any patients with signs or symptoms consistent with cardiac failure should be evaluated and treated.
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