NCPDP Standards Advance Pharmacy Interoperability, AI, and Drug Access

In a rapidly shifting health care environment where technology and data integration are paramount, pharmacy interoperability has become the cornerstone for optimizing patient care.

In the latest episode of the Over the Counter podcast, we sat down with Julia Vu, PharmD, executive vice president of public policy and professional relations at NCPDP, for a deep dive into the standards driving the next era of pharmacy transformation. Drawing on her extensive background in hospital pharmacy and clinical decision support, Vu outlines how the 2026 CMS Interoperability Standards and Prior Authorization for Drugs proposed rule will align processes to reduce patient wait times and administrative burdens.

The discussion also explores the essential role of NCPDP standards, including SCRIPT, Formulary and Benefit, and the Real-Time Prescription Benefit tool, in orchestrating a seamless end-to-end experience for patients—from the doctor’s office to the pharmacy counter. She also addresses the rise of direct-to-consumer (DTC) prescription programs, emphasizing the need for transparency and safety through interoperable data that allows for drug-drug interaction verification across different care points.

A major focus of the conversation is the shift toward interoperable AI, moving beyond isolated technology to standardized communication between AI agents in EHRs and payer systems. Furthermore, Vu highlights the Rural Health Transformation Program, discussing how $50 billion in federal funding and tools like AssureLink are helping pharmacists in expanded roles manage public health measures through patient identity matching and connected data.

For pharmacy professionals looking to navigate new clinical reimbursement pathways, such as those introduced by the Main Street Pharmacy Access Act, this episode provides a vital roadmap. Tune in to the full conversation to hear Julia’s insights on how your practice can leverage these evolving standards to remain united in care.

Stay tuned for weekly podcast episodes of Over the Counter powered by Drug Topics. Check out our most recent episode with Sandra Leal, PharmD, MPH, who discussed the pharmacist’s increasingly prominent role in managed diabetes care as well as the continuous opportunities available for them to expand their scope.