The FDA has approved finerenone (Kerendia, Bayer) for the treatment of adults with chronic kidney disease (CKD) associated with type 2 diabetes.
The FDA has approved finerenone (Kerendia, Bayer) for the treatment of adults
with chronic kidney disease (CKD) associated with type 2 diabetes.1 Finerenone is a nonsteroidal selective mineralocorticoid receptor (MR) antagonist used to reduce the risk of sustained estimated glomerular filtration rate (eGFR) decline, endstage
kidney disease, cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure.1,2
Finerenone is activated by aldosterone and cortisol, and it also regulates gene transcription. Finerenone works by blocking MR-mediated sodium reabsorption
and MR overactivation in epithelial and nonepithelial tissues. Finerenone has high potency and selectivity for the MR.
SGLT2i, GLP-1RA Combination Therapy Offers Robust Protection Against Cardiovascular, Kidney Disease
Published: July 8th 2024 | Updated: July 10th 2024When used together, sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) were able to lower the risk of major adverse cardiovascular events and kidney disease by 11% and 33%, respectively.