Cablivi for Acquired Thrombotic Thrombocytopenic purpura

Cablivi (caplacizumab-yhdp, Sanofi Genzyme)

Indications: Treatment of adult patients with acquired thrombotic thrombocytopenic purpura (aTTP), in combination with plasma exchange and immunosuppressive therapy

Dosage:

• Day 1 of treatment: 11-mg bolus intravenous injection at least 15 min prior to plasma exchange, followed by 11-mg subcutaneous injection after plasma exchange

• 11-mg subcutaneous injection once daily for 30 days following plasma exchange 

• Treatment may be extended for a maximun of 28 days only if persistent underlying diseases remain present

• Discontinue if two or more recurrences of aTTP occur while on Cablivi 

Contraindications: Previous severe hypersensitivity reaction to caplacizumab-yhdp or any of the excipients. 

Click here for more prescribing information