The Food & Drug Administration has approved deferasirox (Exjade, Novartis Pharmaceuticals) for the treatment of chronic iron overload due to blood transfusions (transfusional hemosiderosis) in adults and children age two and older. "Iron overload is a potentially fatal consequence among patients with sickle cell disease, myelodysplastic syndromes, and thalassemia who regularly receive blood transfusions," said Alice Cohen, M.D., director of the division of hematology and oncology at Newark Beth Israel Medical Center, Newark, N.J. If left untreated, excess iron may lead to significant damage to the heart, liver, and other vital organs.