Zyvox use shows increased mortality
Results of a clinical trial comparing linezolid (Zyvox, Pfizer) with vancomycin, oxacillin, or dicloxacillin show that patients treated with linezolid had a higher mortality rate compared with patients treated with other antibiotics.
Results of a clinical trial comparing linezolid (Zyvox, Pfizer) with vancomycin, oxacillin, or dicloxacillin show that patients treated with linezolid had a higher mortality rate compared with patients treated with other antibiotics. The chance of death was higher in patients infected with gram-negative organisms or a mix of gram-negative and gram-positive organisms, or in those patients who had no infection when they entered the study. Patients were being treated for intravascular catheter-related bloodstream infections, including catheter-site infections. Patients treated for gram-positive infections showed no increase in mortality. The FDA reminds practitioners that linezolid is not approved for the treatment of gram-negative catheter-related infections.
To see more Hot off the Press news articles, click here.
To go to the Drug Topics homepage, click here.
Q&A: Pharmacist-Led Diabetes Management Transforms Patient Care and Clinical Outcomes
June 28th 2025An ambulatory care pharmacist program in Washington State dramatically improved diabetes management by reducing A1c levels, increasing medication adherence, and providing comprehensive patient education.
