Tecentriq for Locally Advanced or Metastatic Urothelial Carcinoma

Tecentriq (atezolizumab, Genetech)

Indications: Patients with locally advanced or metastatic urothelial carcinoma

• Not eligble for cisplatin-containing chemotherapy & whose tumors express PD-L1

• Not eligible for any platinum-containing chemotherapy regardless of PD-L1 status

• Have disease progression during or following any platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant chemotherapy

Dosage

• Metastatic Urothelial Carcinoma or Previously Treated NSCLC
• 1200 mg intravenously 60 mins x 3weeks

• 1200 mg IV over 60 minutes, followed by bevacizumab, paclitaxel and carboplatin, on the same day every 3 weeks x4-6

Contraindications: none

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