Rocephin PI updated to reflect calcium interaction

September 13, 2007

Ceftriaxone prescribing information updated to warn of calcium interaction

Revisions have been made to the label of ceftriaxone (Rocephin, Roche) to include warning of the potential risk of crystallization when the antibiotic is used concomitantly with calcium or calcium-containing solutions or products. The update advises healthcare professionals to avoid coadministration, including with continuous infusions of calcium-containing parenterals such as TPN, even via different sites. Ceftriaxone and calcium solutions should not be administered within 48 hours of each other in any patient, regardless of age.

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