Revcovi (elapegademase-lvlr, Lediant Biosciences)
Indications: Adenosine deaminase severe combined immune deficiency (ADA-SCID)
- Starting: 0.4 mg/kg (idea body weight) in 2 intramuscular supplements (0.2 mg/kg twice per week)
- Maintenance dosing: increments of 0.033 mg/kg weekly if...
- trough ADA activity is under 30 mmol/hr/L
- trough deoxyadenosine nucleotides (dAXP) are above 0.02 mmol/L
- the immune reconstitution is inadequate based on the clinical assessment of the patient
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