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Recent revisions to the U.S. Department of Health and Human Services (HHS) Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents will make it easier for clinicians and their patients to identify an appropriate therapeutic regimen from among the increasing number of antiretroviral agents. In earlier versions of the guidelines, commonly used antiretroviral drugs were grouped into columns, and clinicians devised a combination regimen by using agents from one column with those from another. In the latest version, clinicians are provided with a list of suggested combination regimens for the initiation of antiretroviral therapy. The recommended regimens are designated as either "preferred" or "alternative," based on expert opinion and the findings from clinical trials.