Counseling Patients New to Dry Eye Treatment with Tyrvaya® (Varenicline Solution)

Indication
Tyrvaya® (varenicline solution) nasal spray is indicated for the treatment of the signs and symptoms of dry eye disease.

Important Safety Information
The most common adverse reaction reported is 82% of patients was sneezing. Events that were reported in 5-16% of patients were cough, throat irritation, and instillation-site (nose) irritation.

Please click here for full Prescribing Information.

Tyrvaya® (varenicline solution) nasal spray is indicated for the treatment of the signs and symptoms of dry eye disease.

The most common adverse reaction reported in 82% of patients was sneezing. Events that were reported in 5-16% of patients were cough, throat irritation, and instillation-site (nose) irritation.

Pharmacist: Hi Sandra, I’m so happy to see you back. I’m glad you followed up with your eye doctor to discuss how to treat the signs and symptoms of your dry eye disease.

Patient: Thank you for advising me to talk with my eye doctor about my experience with dry eye disease. We reviewed my symptoms and discussed prescription treatment options.

Pharmacist: Excellent. I have your prescription ready in the back, but let’s take a few minutes to review some important information together. Tyrvaya is a new prescription for you—I’m here to answer any questions you may have.

Patient: I do have a question already, maybe you can help. I’ve used eye drops before, but never a nasal spray. Could you tell me how this works?

Pharmacist: I’m glad you asked how Tyrvaya is designed to work. In fact, it is the first and only nasal spray available for dry eye disease. Nasal spray administration provides a different way to treat dry eye disease without administering medication onto already irritated eyes.

Tyrvaya is a preservative-free nasal spray that is believed to activate tear film production from within – helping your body create more natural tears.

There are glands and cells around your eyes that work together to produce tear film. These glands and cells are connected to a nerve inside your nose that is part of your body’s pathway for controlling tear film production. Tyrvaya, when sprayed into your nose, is believed to activate this pathway to produce more of your own natural tear film.

Patient: My eye doctor said something about tear film…I’m not sure what tear film is. Could you tell me what that means?

Pharmacist: When you blink, a layer of tears spreads across the surface of your eyes. This is called tear film. Your naturally occurring tear film is a treasure trove. It’s made up of more than 1,500 different proteins, growth factors, and enzymes. Each valuable component has an important job to do. When your tear film is unstable, your eyes may become dry and uncomfortable, leading to the cycle of dry eye disease.

Patient: Thank you. That makes more sense to me now.

Pharmacist: Let’s take a look at the full Instructions for Use—you will need to review this before you use Tyrvaya, even if you’ve used other nasal sprays. Tyrvaya is sprayed once into each nostril twice a day, about 12 hours apart. If you miss a dose of Tyrvaya, skip that dose and take your next dose at your regular scheduled time. Do not take an extra dose to make up for a missed dose. Tyrvaya is for use in the nose. Do not shake the bottles.

Pharmacist: Ok pop quiz! Can you repeat the administration instructions I just gave you?

Patient: OK I think I can. I’m going to spray Tyrvaya once into each nostril twice a day, about 12 hours apart.

Pharmacist: Great job! Remember, all of this is in the Patient Information and Instructions for Use that comes with your prescription. You will want to refer back to this as you are learning to administer Tyrvaya and each time you get a refill.

Patient: Ok I will.

Pharmacist: There is also a really helpful how to use Tyrvaya video available on tyrvaya.com. I do have a few other tips for administration I want to share.

• Do not spray into your sinuses: Insert and tilt the tip of the nasal spray just past the nasal opening. Aim the tip out towards your ear on the same side of the nostril you’re spraying into.
• Ensure proper tongue placement: Press your tongue to the roof of your mouth.
• Resist inhaling the mist: Breathe gently as you press down completely and release the applicator, just misting the inside of your nostril. The medication will absorb into the wall of the nose, where the nerve you are aiming for is located.

Patient: That makes sense. Are there any side effects I should be on the lookout for after I start taking Tyrvaya?

Pharmacist: In clinical trials, Tyrvaya was shown to be well tolerated with the most common side effects are sneezing (82%), coughing (16%), throat irritation (13%), and nose irritation (8%). No serious side effects related to Tyrvaya were reported in clinical trials. 98% of people who sneezed after using Tyrvaya rated the side effect as mild. Most said it stopped within 1 minute, and none were bothered enough by it to discontinue the trial.

Patient: What happens if I sneeze when I administer it?

Pharmacist: If you sneeze after dosing, you do not need to redose.

Patient: Is there anything else I should know for when I get home? Where should I store it?

Pharmacist: Tyrvaya is supplied in a carton containing 2 multidose glass nasal spray bottles. The two nasal spray bottles contain 60 sprays per bottle. Each carton is equivalent to a 30-day supply when administered as one spray in each nostril twice daily. Do not open the second nasal spray bottle until you have used the entire first bottle.

Alright, you are almost all set here. You have commercial insurance which may make you eligible to sign up for the Tyrvaya savings offer at TyrvayaSavings.com. Has anyone helped you check your eligibility?

Patient: Yes—the lovely technician was so helpful, and I brought the offer with me—right here on my phone.

Pharmacist: Wonderful. I’m going to go grab your prescription and process that savings offer.

TYR-2023-0012 06/24