The rate of decline in the use of atypical antipsychotics in outpatients with dementia accelerated following a black box warning issued by FDA, according to "Trends in Antipsychotic Use in Dementia 1999-2007," a multicenter study of national Veterans Affairs data that appeared in the Archives of General Psychiatry.
The rate of decline in the use of atypical antipsychotics in outpatients with dementia accelerated following a black box warning issued by FDA, according to "Trends in Antipsychotic Use in Dementia 1999-2007," a multicenter study of national Veterans Affairs data that appeared in the Archives of General Psychiatry.
The researchers studied the changes in the use of atypical and conventional antipsychotics in 254,564 patients 65 years of age and older with dementia across 3 periods: no warning (1999-2003), early warning (2003-2005), and black box warning (2005-2007). FDA warned in 2005 that there was a link between increased mortality and the use of atypical antipsychotics in dementia.
Data reveal that in 1999, 17.7% of patients were using atypical or conventional antipsychotics. Overall usage during the no-warning period began to decline (rate per quarter, -0.12%; 95% CI, -0.16 to -0.07; P<.001). The decline continued following issuance of the black box warning (rate, -0.26%; 95% CI, -0.34 to -0.18; P<.001). There was a significant difference between the early and black box warning periods (P=.006). Atypical antipsychotic use increased during the no-warning period (rate, 0.23; 95% CI, 0.17–0.30; P<.001), started to decline during the early-warning period (rate -0.012; 95% CI, -0.14 to 0.11; P=.85), and more sharply declined during the black box warning period (rate, -0.27; 95% CI, -0.36 to -0.18; P<.001).
Specifically, olanzapine and risperidone use declined during the early-warning period, and quetiapine use increased. However, use of all 3 antipsychotics declined during the black box warning period.
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