Are new lice treatments up to scratch?

As a non-neurotoxic treatment, Fairy Tales Hair Care for Children-makers of the natural head lice prevention hair care line, Rosemary Repel-has introduced Lice Good-Bye, available at http://www.fairytaleshaircare.com/ and retailing at $15.95. Then there is LiceGood-Bye Mousse, an enzyme-based shampoo in a pump bottle, which dissolves the glue that nits produce to attach themselves to their host's hair. This enables parents to remove lice and nits from the hair more efficiently. The entire wet hair is covered with "puffs" of mousse. Mild pressure is used to work the mousse through wet hair. This is repeated at least three times or until the entire bottle is used for one person. The mousse is left on for 30 minutes, then the hair is combed and rinsed.

There are also lice treatments in development. Resultz (Piedmont Pharmaceuticals), an experimental rinse, purportedly kills head lice in 10 minutes without causing intolerable adverse effects in children as young as two years and adults up to 59 years. "The product really works well to get rid of head lice, which are becoming more and more resistant to standard treatments," said Nalini Kaul, Ph.D., a scientist at Hill Top Research, Winnipeg, Manitoba, Canada. "The results of our study with the experimental pediculicide demonstrate that it is a safe alternative therapy for the control of head lice," Kaul said. The rinse contains 50% isopropyl myristate and 50% ST-cyclomethicone. The product has been submitted to Health Canada, where it is under regulatory review. U.S. phase III trials are expected to commence sometime this year.

Also awaiting approval for the treatment of lice is Foamix's PerFoam, made with 1% permethrin and two proprietary enhancers. PerFoam is an alcohol-free, drip-free foam that was demonstrated to be safe and to have a 96% efficacy rate in a phase II/III study. In the study, PerFoam was applied to the hair for 10 minutes and then washed. Treatment was repeated 10 days later. The company expects that the new foam formulation will offset the resistance to permethrin seen with shampoo, lotion, and cream rinse formulations. A 2006/07 launch is anticipated for PerFoam.