Advertisement

Adjunct L-methylfolate may improve major depressive symptoms

Augmentation therapy with L-methylfolate may benefit patients who have been diagnosed with major depressive disorder and have had a partial or no response to SSRIs.

Augmentation therapy with L-methylfolate may benefit patients who have been diagnosed with major depressive disorder and have had a partial or no response to SSRIs.

The study, published in the December issue of The American Journal of Psychiatry, reports on data from two trials and demonstrates that adjunctive L-methylfolate 15 mg daily may be a safe and effective treatment for patients who have had a partial response or no response to selective serotonin reuptake inhibitors (SSRIs).

In the first trial, the authors enrolled 148 outpatients with SSRI-resistant major depressive disorder and randomly assigned them in a 2:3:3 ratio to receive L-methylfolate for 60 days (7.5 mg/day for 30 days followed by 15 mg/day for 30 days), placebo for 30 days followed by L-methylfolate (7.5 mg/day) for 30 days, or placebo for 60 days. The second trial was designed identically; however, the L-methylfolate dose was 15 mg/day during both 30-day periods. The authors enrolled 75 patients into the second trial.

Advertisement

Investigators observed no significant difference in outcomes between the treatment groups in trial 1, but in trial 2, adjunctive L-methylfolate at 15 mg/day demonstrated significantly greater efficacy. Twice as many patients achieved response in 30 days and experienced 84% greater reduction in depressive symptoms compared with continued SSRI therapy plus placebo, according to Pamlab, maker of Deplin, a medical food containing L-methylfolate.

The authors found L-methylfolate to be well tolerated, and concluded that "15 mg/day may constitute an effective, safe, and relatively well tolerated treatment strategy for patients with major depressive disorder who have a partial response or no response to SSRIs."

The study was supported by a grant from Pamlab.


Advertisement
Advertisement