Independent and chain drugstore pharmacists have had to address a significant number of new issues during 2006, such as the launching of the Medicare Part D program and new demands on their professional time to assist customers. Perhaps the single most pressing issue facing R.Ph.s, however, is reimbursement. No other issue ignites more debate than how an insurance plan, government program, or patient reimburses pharmacists for their products/services. A growing number of pharmacies across the country are falling into debt, laying off workers, and facing closure due to inadequate reimbursement levels and slow payment. This article summarizes the reimbursement plight pharmacists find themselves in and reviews three attempts under way to help resolve this issue.