
Orforglipron lowered A1C and body weight more than oral semaglutide 25 mg at 52 weeks, but the estimate comes from an indirect comparison.
Treating rheumatoid arthritis is challenging enough as it is without the latest studies linking COX-2 inhibitors, often used as adjunct therapy, with an increased heart risk. These studies have left many RA patients and physicians a bit apprehensive about continuous high-dose therapy.






