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The human immunodeficiency virus (HIV) may be the closest thing to a perfect virus we have encountered. It is variable, it destroys the patient's defenses, it can hide, and it allows time to spread before it kills. Fortunately, it is not highly infectious. Over the past year, there have been a multitude of clinical trials studying various antiretroviral therapies resulting in an accumulation of data. So much so that the Department of Health & Human Services (HHS) has released its newly revised Guidelines for Antiretroviral Agents in HIV-1 Infected Adults and Adolescents for review and comment even though it released the last version just this past March.